Measurement of Steroid Concentrations in Brain Tissue: Methodological Considerations

Measurement of Steroid Concentrations in Brain Tissue: Methodological Considerations

It is well recognized that steroids are synthesized de novo in the brain (neurosteroids). In addition, steroids circulating in the blood enter the brain. Steroids play numerous roles in the brain, such as influencing neural development, adult neuroplasticity, behavior, neuroinflammation, and neurodegenerative diseases such as Alzheimer's disease. In order to understand the regulation and functi...

Methodological considerations in the measurement of subjective well-being 2. METHODOLOGICAL CONSIDERATIONS IN THE MEASUREMENT OF SUBJECTIVE WELL-BEING

P-wave dispersion measurement: Methodological considerations

Well-known difficulties in defining P-wave onset and offset may restrict the accuracy and reproducibility of P-wave dispersion measurements. To achieve greater precision in measuring P-wave dispersion, simultaneous digital recording of all 12 ECG leads and onscreen measurement of P wave characteristics is mandatory to examine atrial fibrillation risk.

Measurement of the pro-hormone of brain type natriuretic peptide (proBNP): methodological considerations and pathophysiological relevance.

Recent studies demonstrated that large amounts of the pro-hormone peptide of brain natriuretic peptide (proBNP) can be detected in plasma of healthy subjects and in particular of patients with heart failure. As a result, a great part of B-type natriuretic peptides measured in patients with cardio-vascular disease may be devoid of biological activity. These findings stimulated the set up of spec...

Methodological considerations in longitudinal morphometry of traumatic brain injury

Traumatic brain injury (TBI) has recently been reconceptualized as a chronic, evolving disease process. This new view necessitates quantitative assessment of post-injury changes in brain structure that may allow more accurate monitoring and prediction of recovery. In particular, TBI is known to trigger neurodegenerative processes and therefore quantifying progression of diffuse atrophy over tim...